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Arterial stiffness in people with Type 2 diabetes and obstructive sleep apnoea
Author(s) -
Hvelplund Kristiansen M.,
Banghøj A. M.,
Laugesen E.,
Tarnow L.
Publication year - 2018
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.13666
Subject(s) - medicine , pulse wave velocity , arterial stiffness , type 2 diabetes , blood pressure , diabetes mellitus , cardiology , sleep (system call) , pulse wave analysis , endocrinology , computer science , operating system
Aims To examine whether people with Type 2 diabetes with concurrent obstructive sleep apnoea have increased arterial stiffness as compared with people with Type 2 diabetes without obstructive sleep apnoea. Methods In a study with a case–control design, 40 people with Type 2 diabetes and treatment‐naïve moderate to severe obstructive sleep apnoea (Apnoea‐Hypopnoea Index ≥15) and a control group of 31 people with Type 2 diabetes without obstructive sleep apnoea (Apnoea‐Hypopnoea Index <5) were examined. Obstructive sleep apnoea status was evaluated using the ApneaLink ® + home‐monitoring device (Resmed Inc., San Diego, CA , USA ), providing the Apnoea‐Hypopnoea Index scores. Arterial stiffness was assessed according to carotid‐femoral pulse wave velocity using the Sphygmocor device and the oscillometric Mobil‐O‐Graph ® (I.E.M. GmbH, Stolberg, Germany). Results Carotid‐femoral pulse wave velocity was not significantly different between participants with Type 2 diabetes with obstructive sleep apnoea and those without obstructive sleep apnoea (10.7±2.2 m/s vs 10.3±2.1 m/s; P =0.513), whereas oscillometric pulse wave velocity was significantly higher in participants with Type 2 diabetes with obstructive sleep apnoea than in those without obstructive sleep apnoea (9.5±1.0 m/s vs 8.6±1.4 m/s; P =0.002). In multiple regression analysis, age ( P =0.002), gender (men; P =0.018) and HbA 1c ( P =0.027) were associated with carotid‐femoral pulse wave velocity, and systolic blood pressure ( P =0.004) and age ( P <0.001) were associated with oscillometric pulse wave velocity. After adjustment, presence of obstructive sleep apnoea was not independently associated with pulse wave velocity whether assessed by tonometry or oscillometry. Conclusion In conclusion, the present study did not find an age‐ and blood pressure‐independent association between moderate to severe obstructive sleep apnoea and arterial stiffness in non‐sleepy people with Type 2 diabetes. (Clinical trial registration number: NCT02482584)