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Sleep duration and progression to diabetes in people with prediabetes defined by HbA 1c concentration
Author(s) -
Kim C.W.,
Chang Y.,
Sung E.,
Ryu S.
Publication year - 2017
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.13432
Subject(s) - prediabetes , medicine , diabetes mellitus , hazard ratio , cohort , insulin resistance , proportional hazards model , incidence (geometry) , endocrinology , type 2 diabetes , confidence interval , physics , optics
Aims To evaluate the association between sleep duration and the risk of progression to diabetes among people with prediabetes, defined by HbA 1c values. Methods We conducted a cohort study in 17 983 adults who underwent health check‐up examinations, including assessments of sleep duration and quality. Diabetes was defined as either HbA 1c ≥48 mmol/mol (6.5%), or the use of antidiabetic medication. Time‐dependent proportional hazards models were used to evaluate the association between sleep duration and the risk of progression to diabetes. Results During 31,582 person‐years of follow‐up, 664 incident cases of diabetes were identified; the incidence rate was 21.0 per 1000 person‐years. The multivariate adjusted hazard ratios for progression to diabetes in people with sleep durations of ≤5, 6 and ≥8 h compared with 7 h were 1.68 (95% CI 1.30–2.16), 1.44 (95% CI 1.17–1.76) and 1.23 (95% CI 0.85–1.78), respectively ( P for quadratic trend <0.001). This association was partially mediated by biomarkers of adiposity, fatty liver and insulin resistance. Conclusion In this large study in young and middle‐aged adults with prediabetes, we found an association between short sleep duration and the risk of progression to diabetes. Our findings suggest that sufficient sleep duration is important for delaying or preventing the progression of prediabetes to diabetes.