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Reproducibility of the plasma glucose response to moderate‐intensity exercise in adolescents with Type 1 diabetes
Author(s) -
Abraham M. B.,
Davey R. J.,
Cooper M. N.,
Paramalingam N.,
O'Grady M. J.,
Ly T. T.,
Jones T. W.,
Fournier P. A.,
Davis E. A.
Publication year - 2017
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.13395
Subject(s) - medicine , basal (medicine) , type 2 diabetes , endocrinology , diabetes mellitus , insulin , reproducibility , plasma glucose , confidence interval , statistics , mathematics
Aims The aim of the study was to evaluate the reproducibility of the plasma glucose response to moderate‐intensity exercise performed on different days under controlled conditions in adolescents with Type 1 diabetes. Methods Eight adolescents with Type 1 diabetes on continuous subcutaneous insulin infusion completed two exercise sessions, each on two separate days, under basal insulin and fasting conditions. On each day, participants cycled twice for 30 min at 55% of their peak rate of oxygen consumption, with each exercise session separated by a 30‐min rest. Results Plasma insulin levels were similar between testing days and exercise sessions. The mean absolute drop in plasma glucose from the commencement to the end of exercise was 1.6 ± 0.5 mmol/l on day 1 and 1.9 ± 0.7 mmol/l on day 2 ( P = 0.3). In response to the first exercise session, plasma glucose levels relative to baseline did not change significantly (0.2 ± 0.6 and –0.2 ± 0.5 mmol/l on days 1 and 2). By contrast, the change in plasma glucose during the second exercise session was –1.1 ± 0.7 and –1.3 ± 0.7mmol/l on days 1 and 2, respectively. The mean absolute intra‐individual difference in the change in plasma glucose between testing days were 0.7 ± 0.5 [95% confidence interval ( CI ) 0.4–1.0] and 0.7 ± 0.4 (95% CI 0.4–1.0) mmol/l, at the end of the first and second exercise sessions respectively. Conclusions The plasma glucose response to moderate‐intensity exercise under similar glycaemic and basal insulin conditions can be reproducible in adolescents with Type 1 diabetes.