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Glucose‐6‐phosphate dehydrogenase deficiency induced haemolysis in a woman with newly diagnosed diabetes after normalisation of hyperglycaemia
Author(s) -
ALjishi F.,
ALDarwish M.
Publication year - 2017
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.13385
Subject(s) - medicine , haemolysis , glucose 6 phosphate dehydrogenase deficiency , diabetes mellitus , hemolysis , incidence (geometry) , pediatrics , hemolytic anemia , glucosephosphate dehydrogenase deficiency , endocrinology , glucose 6 phosphate dehydrogenase , dehydrogenase , immunology , enzyme , biochemistry , chemistry , physics , optics
Background The association between diabetes and G6PD deficiency is still a matter of debate. Hemolysis due to G6PD deficiency in people with diabetes has been reported, but is uncommon. To date, twenty‐three cases have been reported from 12 different countries. Case report We reported a 19‐year‐old Saudi women newly diagnosed with Type 1 diabetes in whom hemolytic crises occurred soon after normalization of hyperglycemia and revealed a G6PD deficiency. We reviewed the pertinent literature of this phenomenon and discussed the relevant theories. Conclusion We conclude that in order to reduce the risk of hemolysis, in an area with high incidence of G6PD deficiency, screening of the enzyme activity should be considered in newly diagnosed people with diabetes. In case of G6PD deficiency, it is advisable to correct plasma glucose level gradually in order to avoid the rapid decline in glucose availability.