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FUT 2 non‐secretor status is associated with Type 1 diabetes susceptibility in Japanese children
Author(s) -
Ihara K.,
Fukano C.,
Ayabe T.,
Fukami M.,
Ogata T.,
Kawamura T.,
Urakami T.,
Kikuchi N.,
Yokota I.,
Takemoto K.,
Mukai T.,
Nishii A.,
Kikuchi T.,
Mori T.,
Shimura N.,
Sasaki G.,
Kizu R.,
Takubo N.,
Soneda S.,
Fujisawa T.,
Takaya R.,
Kizaki Z.,
Kanzaki S.,
Hanaki K.,
Matsuura N.,
Kasahara Y.,
Kosaka K.,
Takahashi T.,
Minamitani K.,
Matsuo S.,
Mochizuki H.,
Kobayashi K.,
Koike A.,
Horikawa R.,
Teno S.,
Tsubouchi K.,
Mochizuki T.,
Igarashi Y.,
Amemiya S.,
Sugihara S.
Publication year - 2017
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.13288
Subject(s) - medicine , abo blood group system , genotype , odds ratio , type 2 diabetes , diabetes mellitus , cohort , type 1 diabetes , gene , genetics , endocrinology , biology
Aim To examine the contribution of the FUT 2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children. Methods We analysed FUT 2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT 2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. Results The se2 genotype (c.385A>T) of the FUT 2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20–2.35); corrected P value = 0.0075]. Conclusions The FUT 2 gene contributed to the development of Type 1 diabetes in the present cohort of Japanese children.