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Objectively measured sedentary time, physical activity and kidney function in people with recently diagnosed Type 2 diabetes: a prospective cohort analysis
Author(s) -
Guo V. YW.,
Brage S.,
Ekelund U.,
Griffin S. J.,
Simmons R. K.
Publication year - 2016
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12886
Subject(s) - medicine , renal function , creatinine , waist , prospective cohort study , type 2 diabetes , body mass index , diabetes mellitus , blood pressure , urine , endocrinology
Aim To assess the prospective association between objectively measured physical activity and kidney function over 4 years in people with Type 2 diabetes. Methods Individuals (120 women and 206 men) participating in the ADDITION ‐Plus trial underwent assessment of sedentary time ( SED ‐time), time spent in moderate‐to‐vigorous‐intensity physical activity ( MVPA ) and total physical activity energy expenditure ( PAEE ) using a combined heart rate and movement sensor, and kidney function [estimated glomerular filtration rate ( eGFR ), serum creatinine and urine albumin‐to‐creatinine ratio ( ACR )] at baseline and after 4 years of follow‐up. Multivariate regression was used to quantify the association between change in SED ‐time, MVPA and PAEE and kidney measures at four‐year follow‐up, adjusting for change in current smoking status, waist circumference, HbA 1c , systolic blood pressure, triglycerides and medication usage. Results Over 4 years, there was a decline in eGFR values from 87.3 to 81.7 ml/min/1.73m 2 ( P < 0.001); the prevalence of reduced eGFR ( eGFR < 60 ml/min/1.73m 2 ) increased from 6.1 to 13.2% ( P < 0.001). There were small increases in serum creatinine (median: 81–84 μmol/l, P < 0.001) and urine ACR (median: 0.9–1.0 mg/mmol, P = 0.005). Increases in SED ‐time were associated with increases in serum creatinine after adjustment for MVPA and cardiovascular risk factors (β = 0.013, 95% CI : 0.001, 0.03). Conversely, increases in PAEE were associated with reductions in serum creatinine (β = –0.001, 95% CI : –0.003, –0.0001). Conclusion Reducing time spent sedentary and increasing overall physical activity may offer intervention opportunities to improve kidney function among individuals with diabetes. (Trial Registry no. ISRCTN 99175498)