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Killer immunoglobulin receptor genes and their HLA –C ligand are associated with Type 1 diabetes in an Eastern Indian population
Author(s) -
Sanjeevi S.,
Sun C.,
Kanungo A.,
Sanjeevi C. B.
Publication year - 2016
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12815
Subject(s) - human leukocyte antigen , medicine , genotyping , diabetes mellitus , immunology , type 2 diabetes , receptor , type 1 diabetes , population , polymorphism (computer science) , disease , gene , allele , genotype , genetics , antigen , endocrinology , biology , environmental health
Aim Killer immunoglobulin‐like receptors ( KIR s) and their interaction with HLA class I ligands have been shown to be associated with Type 1 diabetes mellitus. The aim of our study was to investigate the influence of KIR genes and their HLA –C ligands for susceptibility to Type 1 diabetes in patients from Eastern India. Methods A total of 135 patients with Type 1 diabetes and 98 healthy subjects from Eastern India were typed for KIR genes and HLA –C ligands using PCR ‐based genotyping. The frequencies of these genes were compared between patients and controls. Results Comparison of KIR genes between Type 1 diabetes patients and healthy subjects revealed significantly different frequencies of KIR s 2 DL 2 and 2 DS 4. The presence of HLA –C1 was negatively associated with disease. The presence of both HLA –C1 and ‐C2 showed a negative association with Type 1 diabetes, whereas the absence of C1 and presence of C2 was positively associated with disease. Stratification analysis of HLA –C ligands and KIR s showed significant associations between Type 1 diabetes and 2DL2+/C1−, 2DL2−/C1+, 2DL3+/C1+, 2DL3+/C1− and 2DS2+/C1−. Conclusions Our results suggest that the interaction of KIR s with HLA –C ligands are significant and certain combinations contribute to susceptibility to and protection against Type 1 diabetes.