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Mental health in early pregnancy is associated with pregnancy outcome in women with pregestational diabetes
Author(s) -
Callesen N. F.,
Secher A. L.,
Cramon P.,
Ringholm L.,
Watt T.,
Damm P.,
Mathiesen E. R.
Publication year - 2015
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12777
Subject(s) - medicine , pregnancy , anxiety , obstetrics , edinburgh postnatal depression scale , gestational diabetes , depression (economics) , birth weight , diabetes mellitus , gestational age , hospital anxiety and depression scale , mental health , gestation , psychiatry , depressive symptoms , endocrinology , genetics , macroeconomics , economics , biology
Aim To explore the role of early pregnancy health‐related quality of life, anxiety, depression and locus of control for pregnancy outcome in women with pregestational diabetes. Methods This was a cohort study of 148 pregnant women with pregestational diabetes (118 with Type 1 diabetes and 30 with Type 2 diabetes), who completed three internationally validated questionnaires: the 36‐item Short‐Form Health Survey, the Hospital Anxiety and Depression Scale and the Multidimensional Health Locus of Control survey at 8 weeks. Selected pregnancy outcomes were preterm delivery (< 37 weeks) and large for gestational age infants (birth weight > 90 th percentile). Differences between groups in the questionnaires were analysed using an unpaired t ‐test. Results Women with preterm deliveries ( n = 28) had lower (i.e. worse) mean ( sd ) quality‐of‐life scores for the two 36‐item Short‐Form Health Survey scales, Role‐Emotional [58.3 (38.1) vs. 82.9 (31.3); P = 0.0005] and Mental Health [67.7 (20.4) vs. 75.2 (15.8), P = 0.04], and a lower score for the 36‐item Short‐Form Health Survey scale Mental Component Summary (42.8 (13.1) vs. 48.8 (9.7), P = 0.03) in early pregnancy, compared with women with term deliveries. Depression symptoms (Hospital Anxiety and Depression Scale depression score ≥ 8) were more frequent in women with preterm vs. term deliveries (seven (25%) vs. six women (5%); P = 0.003), while levels of anxiety and locus of control were similar in these two groups. No difference in early pregnancy scores for health‐related quality of life, anxiety, depression and locus of control were seen in women delivering large or appropriate for gestational age infants. Conclusions Poor mental quality of life and the presence of depressive symptoms in early pregnancy were associated with preterm delivery in women with pregestational diabetes.