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Association between pulse pressure and risk of hospital admissions for cardiovascular events among people with Type 2 diabetes: a population‐based case–control study
Author(s) -
Yu D.,
Simmons D.
Publication year - 2015
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12693
Subject(s) - medicine , type 2 diabetes , pulse pressure , diabetes mellitus , population , blood pressure , emergency medicine , environmental health , endocrinology
Aim To investigate the association between pulse pressure and risk of hospitalization for cardiovascular events among people with Type 2 diabetes. Methods A population‐based case–control study was carried out using data from medical databases. A total of 588 people with Type 2 diabetes from 18 general practices in Cambridgeshire recorded a first hospitalization for a cardiovascular event between 2009 and 2011, and a total of 2920 age‐matched, gender‐matched and practice‐matched control subjects with Type 2 diabetes were selected based on risk‐set sampling. Pulse pressure was assessed before admission in 2008–2009. Further dose–response relationships between pulse pressure and risks were explored using spline models. Results There was a non‐linear relationship between pulse pressure and the risk of hospitalization for a cardiovascular event ( P < 0.001 for linearity test). The pulse pressure associated with the lowest risk of hospitalization for a cardiovascular event was 61 (95% CI 57–63) mmHg. Conclusion In people with Type 2 diabetes, pulse pressure is a good predictor of risk of hospitalization for cardiovascular events. The risk is lowest with a pulse pressure of 57–63 mmHg.