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Early menarche increases the risk of Type 2 diabetes in young and middle‐aged Korean women
Author(s) -
Lim J. S.,
Lee H. S.,
Kim E. Y.,
Yi K. H.,
Hwang J. S.
Publication year - 2015
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12653
Subject(s) - medicine , menarche , national health and nutrition examination survey , odds ratio , type 2 diabetes , diabetes mellitus , demography , body mass index , confidence interval , type 1 diabetes , endocrinology , population , environmental health , sociology
Abstract Aims To investigate the association between early menarche (menarche age < 12 years) and Type 2 diabetes mellitus in young and middle‐aged Korean women. Methods We analysed data for 4657 women aged 20–50 years from the Fourth Korea National Health and Nutrition Examination Survey ( KNHANES IV ) (2007–2009). Results The prevalence of Type 2 diabetes was 2.8%. Women with early menarche had a higher prevalence of impaired fasting glucose than did women with later menarche (age ≥ 12 years) in the 20–30 age group (7.4% vs. 3.0%), and a higher prevalence of diabetes in the 30–40 (6.3% vs. 1.7%) and 40–50 (18.5% vs. 4.4%) age groups. The odds ratio ( OR ) of Type 2 diabetes in women with early menarche was 3.61 [95% confidence interval ( CI ), 1.90–6.88] after adjusting for age. In multivariate regression, the OR of Type 2 diabetes decreased to 2.52 (95% CI , 1.29–4.94) after further adjusting for BMI . However, the OR decreased to 2.04 (95% CI , 0.95–4.39) without significance after adjusting for HOMA – IR . Conclusions Early menarche increased the risk of Type 2 diabetes in young and middle‐aged Korean women although adulthood adiposity attenuated the relationship. Knowledge of age at menarche is important in identifying women at risk for diabetes.