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Long‐term incidence of vitrectomy and associated risk factors in young Danish patients with Type 1 diabetes: the Danish Cohort of Paediatric Diabetes 1987
Author(s) -
Broe R.,
Rasmussen M. L.,
FrydkjaerOlsen U.,
Olsen B. S.,
Mortensen H. B.,
Peto T.,
Grauslund J.
Publication year - 2015
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12628
Subject(s) - medicine , hazard ratio , vitrectomy , diabetic retinopathy , danish , incidence (geometry) , type 2 diabetes , proportional hazards model , cohort study , diabetes mellitus , retinopathy , cohort , risk factor , prospective cohort study , surgery , confidence interval , endocrinology , visual acuity , linguistics , philosophy , physics , optics
Aims To examine the long‐term incidence of vitrectomy in young people with Type 1 diabetes. Methods We prospectively studied 324 people with Type 1 diabetes who participated in baseline examinations in 1995. Surgical history was obtained from the Danish National Patient Registry in April 2012. Results During the 17‐year study period, 39 people (12.0%) underwent vitrectomy at least once. The mean age and diabetes duration at first vitrectomy were 29.8 and 22.9 years, respectively, and 64.1% of the participants were men. In multivariable Cox regression analysis, baseline age (hazard ratio 0.81 per 1 year increase), BMI (hazard ratio 1.21 per 1 kg/m 2 increase), HbA 1c (hazard ratio 1.72 per 1% increase) and diabetic retinopathy (hazard ratio 2.85 and 6.07 for mild and moderate/severe diabetic retinopathy vs none, respectively) were independent predictors of vitrectomy ( P < 0.05 for all variables). Conclusions Vitrectomy is a relatively common procedure in young people with Type 1 diabetes, with poor glycaemic control being the strongest modifiable risk factor.