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Positive association of free triiodothyronine with pancreatic β‐cell function in people with prediabetes
Author(s) -
Oda T.,
Taneichi H.,
Takahashi K.,
Togashi H.,
Hangai M.,
Nakagawa R.,
Ono M.,
Matsui M.,
Sasai T.,
Nagasawa K.,
Honma H.,
Kajiwara T.,
Takahashi Y.,
Takebe N.,
Ishigaki Y.,
Satoh J.
Publication year - 2015
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12589
Subject(s) - prediabetes , medicine , endocrinology , euthyroid , triiodothyronine , thyroid function , insulin , blood sugar regulation , diabetes mellitus , glucose homeostasis , impaired glucose tolerance , islet , thyroid , hormone , insulin resistance , type 2 diabetes
Aim To analyse the effects of thyroid hormones on β‐cell function and glucose metabolism in people with prediabetes who are euthyroid. Methods A total of 111 people who were euthyroid underwent 75‐g oral glucose tolerance tests, of whom 52 were assigned to the normal glucose tolerance and 59 to the prediabetes groups. Homeostatic model assessment of β‐cell function, insulinogenic index and areas under the curve for insulin and glucose were evaluated as indices of pancreatic β‐cell function. Results In both groups, BMI , fasting insulin, homeostasis model assessment ratio and HDL cholesterol correlated significantly with all indices of pancreatic β‐cell function. Free triiodothyronine correlated positively with all insulin secretion indices in the prediabetes group. Multiple linear regression analysis showed that free triiodothyronine was an independent variable that had a positive correlation with all indices of β‐cell function in the prediabetes group. By contrast, no such correlation was found in the normal glucose tolerance group. Conclusions Free triiodothyronine is associated with both basal and glucose‐stimulated insulin secretion in people with prediabetes who are euthyroid; therefore, the regulation of insulin secretion by thyroid hormones is a potentially novel therapeutic target for the treatment of diabetes.