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Not so sweet: autoimmune diabetes mellitus on triple therapy for chronic hepatitis C infection
Author(s) -
Blanchard E.,
Vickers C. R.,
Samaras K.
Publication year - 2015
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12585
Subject(s) - medicine , ribavirin , hepatitis c , pegylated interferon , hepatitis c virus , diabetes mellitus , immunology , hepatitis , virus , endocrinology
Background Triple therapy with pegylated interferon, ribavirin and a protease inhibitor has proven efficacy in hepatitis C infection and is currently the standard of care. Interferon‐based therapies have been, rarely, associated with the development of Type 1 diabetes mellitus, but few cases have yet been reported in triple therapy for hepatitis C. Case report We describe a case of autoimmune Type 1 diabetes developing in a 23‐year‐old woman after initiation of triple therapy for chronic hepatitis C virus infection. The patient had the IL ‐28B gene polymorphism rs12979860 CT genotype, which is associated not only with antiviral therapy response but also with diabetes risk after liver transplantation for hepatitis C. Conclusion Further studies are required to determine which individual characteristics may identify patients who are at risk of developing Type 1 diabetes when treated with interferon‐based regimens for hepatitis C infection.