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Atherogenic dyslipidaemic profiles associated with the development of Type 2 diabetes: a 3.1‐year longitudinal study
Author(s) -
Hwang Y.C.,
Ahn H.Y.,
Yu S.H.,
Park S.W.,
Park C.Y.
Publication year - 2014
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12278
Subject(s) - medicine , type 2 diabetes , diabetes mellitus , cardiology , endocrinology
Aims While there is thought to be an association between glucose and lipid metabolism, it is largely unknown whether apolipoprotein B and non‐high density lipoprotein (HDL) cholesterol are associated with the development of Type 2 diabetes. It is also unknown whether these atherogenic dyslipidaemic profiles have a stronger association with diabetes risk compared with conventional lipid measurements. Methods A total of 118 429 subjects without diabetes (70 980 men and 47 449 women), aged 17–90 years (mean age 39.6 years), were enrolled in this study and followed for a mean duration of 3.1 years. Results Apolipoprotein B and non‐HDL cholesterol levels showed a strong association with the development of Type 2 diabetes compared with conventional lipid measurements and their ratios [hazard ratio per 1 sd ; 1.39 (95% CI 1.37–1.42) and 1.38 (95% CI 1.35–1.40), respectively; both P < 0.001]. The Kaplan–Meier survival curve demonstrated that Type 2 diabetes developed more frequently as apolipoprotein B or non‐HDL cholesterol levels increased across quartiles (both P < 0.001). In multivariate Cox regression analyses, both apolipoprotein B and non‐HDL cholesterol were associated with the development of Type 2 diabetes, independent of other risk factor including age, sex, waist circumference, family history of diabetes, fasting serum glucose and insulin levels, HbA 1c , systolic blood pressure and other conventional lipid measurements [hazard ratio per 1 sd ; 1.14 (95% CI 1.11–1.18) and 1.13 (95% CI 1.10–1.16), respectively; both P < 0.001]. Conclusions Atherogenic dyslipidaemia was more strongly associated with the development of Type 2 diabetes than conventional lipid measurements, and this effect was independent of other well‐established risk factor for diabetes.