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Waist circumference is genetically correlated with incident Type 2 diabetes in Mexican‐American families
Author(s) -
Mamtani M.,
Kulkarni H.,
Dyer T. D.,
Almasy L.,
Mahaney M. C.,
Duggirala R.,
Comuzzie A. G.,
Blangero J.,
Curran J. E.
Publication year - 2014
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/dme.12266
Subject(s) - waist , circumference , medicine , anthropometry , type 2 diabetes , genetic correlation , diabetes mellitus , waist to height ratio , correlation , waist–hip ratio , body mass index , demography , endocrinology , environmental health , genetic variation , population , geometry , mathematics , sociology
Aims We aimed to determine the genetic and environmental correlation between various anthropometric indexes and incident Type 2 diabetes with a focus on waist circumference. Methods We used the data on extended Mexican‐American families (808 subjects, 7617.92 person‐years follow‐up) from the San Antonio Family Heart Study and estimated the genetic and environmental correlations of 16 anthropometric indexes with the genetic liability of incident Type 2 diabetes. We performed bivariate trait analyses using the solar software package. Results All 16 anthropometric indexes were significantly heritable (range of heritabilities 0.24–0.99). Thirteen indexes were found to have significant environmental correlation with the liability of incident Type 2 diabetes. In contrast, only anthropometric indexes consisting of waist circumference (waist circumference, waist–hip ratio and waist–height ratio) were significantly genetically correlated (genetic correlation coefficients: 0.45, 0.55 and 0.44, respectively) with the liability of incident Type 2 diabetes. We did not observe such a correlation for BMI . Conclusions Waist circumference as a predictor of future Type 2 diabetes is supported by the finding that they share common genetic influences.