The continued efficacy of repeated single‐event multi‐level chemoneurolysis in children with cerebral palsy | Zendy

Teerada  Ploypetch | Zendy; Hilary F. Armstrong | Zendy; Heakyung  Kim | Zendy

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The continued efficacy of repeated single‐event multi‐level chemoneurolysis in children with cerebral palsy

Author(s) -

Teerada Ploypetch,

Hilary F. Armstrong,

Heakyung Kim

Publication year - 2015

Publication title -

developmental medicine and child neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.658

H-Index - 143

eISSN - 1469-8749

pISSN - 0012-1622

DOI - 10.1111/dmcn.48_12886

Subject(s) - cerebral palsy , medicine , event (particle physics) , physical medicine and rehabilitation , audiology , pediatrics , physics , quantum mechanics

Repeated Botulinum toxin-A (BTX-A) injections have shown to be less effective after 2-3 rounds in children with spasticity1 due to antibody formation from frequent treatment & receiving higher weight-adapted maximum dose per treatment.2 Single-Event Multi-Level Chemoneurolysis (SEMLC) uses 5% phenol/45% alcohol in addition to BTX-A for cases, whose maximum dose of BTXA was not sufficient for their condition, enabling to treat multi-level spasticity without overdosing either agent. 249 SEMLC procedures were reviewed, 77% used BTX-A plus phenol/alcohol and 23% used BTX-A only. The number of SEMLCs per patient: median = 5 (2 7). The mean total dose of OnabotulinumtoxinA was 282.35 units, 12.44 units/kg. RESULTS

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