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The continued efficacy of repeated single‐event multi‐level chemoneurolysis in children with cerebral palsy
Author(s) -
Teerada Ploypetch,
Hilary F. Armstrong,
Heakyung Kim
Publication year - 2015
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.48_12886
Subject(s) - cerebral palsy , medicine , event (particle physics) , physical medicine and rehabilitation , audiology , pediatrics , physics , quantum mechanics
Repeated Botulinum toxin-A (BTX-A) injections have shown to be less effective after 2-3 rounds in children with spasticity1 due to antibody formation from frequent treatment & receiving higher weight-adapted maximum dose per treatment.2 Single-Event Multi-Level Chemoneurolysis (SEMLC) uses 5% phenol/45% alcohol in addition to BTX-A for cases, whose maximum dose of BTXA was not sufficient for their condition, enabling to treat multi-level spasticity without overdosing either agent. 249 SEMLC procedures were reviewed, 77% used BTX-A plus phenol/alcohol and 23% used BTX-A only. The number of SEMLCs per patient: median = 5 (2 7). The mean total dose of OnabotulinumtoxinA was 282.35 units, 12.44 units/kg. RESULTS