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Hammersmith Infant Neurological Examination and long‐term cognitive outcome in children born very preterm
Author(s) -
Uusitalo Karoliina,
Haataja Leena,
Nyman Anna,
Lehtonen Tuomo,
Setänen Sirkku
Publication year - 2021
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.14873
Subject(s) - wechsler preschool and primary scale of intelligence , pediatrics , neurological examination , neurocognitive , medicine , gestational age , wechsler intelligence scale for children , cerebral palsy , wechsler adult intelligence scale , odds ratio , intelligence quotient , confidence interval , prospective cohort study , psychology , cognition , pregnancy , physical therapy , psychiatry , biology , genetics
Aim To study the association between the Hammersmith Infant Neurological Examination (HINE) at age 2 years and neurocognition at age 11 years in children born very preterm. We hypothesized that the HINE at 2 years would be associated with neurocognition, that is, neurological, motor, and cognitive outcomes at 11 years. Method A total of 174 children (mean gestational age 29.0wks, SD 2.7; minimum 23.0, maximum 35.9; 95 [55%] males, 79 [45%] females) born very preterm (birthweight ≤1500g/gestational age <32wks), were included in a prospective cohort recruited from 2001 to 2006 in Turku, Finland. The HINE was performed at 2 years’ corrected age. Neurocognition at 11 years was assessed with the Touwen neurological examination, Movement Assessment Battery for Children, Second Edition (MABC‐2), and full‐scale IQ (Wechsler Intelligence Scale for Children, Fourth Edition). Results The HINE global score was associated with the results of the Touwen neurological examination (odds ratio [OR]=0.9, 95% confidence interval [CI] 0.8–0.9, p =0.001), MABC‐2 ( β =1.4, 95% CI 0.7–2.2, p <0.001), and full‐scale IQ ( β =1.2, 95% CI 0.8–1.7, p <0.001), even when adjusted. When children with cerebral palsy (CP) were excluded, the HINE was still associated with full‐scale IQ (unadjusted β =1.2, 95% CI 0.3–2.1, p =0.01). Interpretation A higher HINE global score at 2 years was associated with better general intelligence at 11 years even in children without CP. The HINE may be a useful tool to detect children at risk for later cognitive impairment.What this paper adds A Hammersmith Infant Neurological Examination (HINE) global score at 2 years was associated with long‐term neurocognitive function. Severe cognitive impairment was significantly more common in 11‐year‐old children with complex minor neurological dysfunction compared to typically developing children. The HINE performed at 2 years detects risks of cognitive impairment at 11 years in children born very preterm. A higher HINE score at 2 years was associated with better general intelligence at 11 years.