Premium
Independent walking and cognitive development in preschool children with Dravet syndrome
Author(s) -
Verheyen Karen,
Wyers Lore,
Del Felice Alessandra,
Schoonjans AnSofie,
Ceulemans Berten,
Van de Walle Patricia,
Hallemans Ann
Publication year - 2021
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.14738
Subject(s) - dravet syndrome , cognition , cognitive development , intelligence quotient , effects of sleep deprivation on cognitive performance , pediatrics , motor skill , psychomotor learning , child development , psychology , medicine , developmental psychology , epilepsy , psychiatry
Aim To investigate the relation between cognitive and motor development in preschool aged children with Dravet syndrome, in particular between the age of independent walking and cognitive development. Method Results of cognitive and motor developmental assessments and the age of independent walking were retrieved retrospectively from the medical records of 33 children (17 males, 16 females; mean age at last evaluation 33.2mo, SD 8.2mo, range 9–48mo) diagnosed with Dravet syndrome. Cognitive and motor developmental age, derived from the Bayley Scales of Infant Development or through standardized neurodevelopmental assessment, were converted into cognitive and motor developmental quotients. Multiple test scores per child were included. Results A strong positive relation was found between cognitive and motor developmental quotient (Pearson r =0.854; p <0.001) in 20 children (slope=0.75; 95% CI: 0.54–0.95). A later age of independent walking was associated with a lower cognitive developmental quotient (28 children; p <0.001; slope=−1.01; 95% CI: −1.53 to −0.49). A higher cognitive developmental quotient was seen in children with an age at testing younger than 24 months. The cognitive developmental quotient of children with a delay in independent walking (>17.6mo) was significantly lower than those without a delay ( p =0.006). Interpretation A strong relation exists between cognitive and motor development. Furthermore, the age of independent walking might be an important indicator of the development of children with Dravet syndrome. What this paper adds Cognitive and motor development are strongly related in children with Dravet syndrome. Later age of independent walking is associated with worse cognitive development in children with Dravet syndrome.