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Stroke transcranial Doppler in children with human immunodeficiency virus
Author(s) -
Dlamini Nomazulu,
Pohl Keith,
Eley Brian,
Van Toorn Ronald,
Kilborn Tracy,
Padayachee Soundrie,
Pontigon AnnMarie,
Kirkham Fenella J,
Wilmshurst Jo
Publication year - 2020
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.14439
Subject(s) - medicine , interquartile range , stroke (engine) , transcranial doppler , asymptomatic , middle cerebral artery , hemiparesis , cardiology , pediatrics , ischemia , angiography , mechanical engineering , engineering
Aims To describe stroke syndromes and transcranial Doppler ( TCD ) findings in children with human immunodeficiency virus ( HIV ) and examine the associations between TCD and clinical and laboratory data. Method We enrolled 42 children (24 males, 18 females) with HIV (median age=7y 6mo; 2y 7mo–15y 6mo), with and without stroke who underwent a TCD examination of the anterior and posterior circulations to derive time‐averaged maximum mean velocity ( TAMMV ) measurements for comparison with previous studies. Clinical and laboratory variables were extracted from the medical records. Results Of the 42 children with HIV , five had right‐sided hemiparesis, three had chronic lung disease, two occurred post‐varicella infection, one after herpetic oral ulceration, and one had a poorly functioning left ventricle. Neuroimaging showed middle cerebral artery ( MCA ) TAMMV greater than 200cm/s, moyamoya‐like arteriopathy, left basal ganglia infarction with ipsilateral stenosis, hygroma consistent with venous thrombosis, and a hyperdense left MCA . Eight neurologically asymptomatic children had atypical TCD . The CD 4 cell count was non‐significantly lower in 6 out of 30 children with atypical TCD (median=21.5; interquartile range=16.1–26.5) compared with the remainder (median=29; interquartile range=21.3–35.0; p =0.09). Interpretation A variety of stroke syndromes occur in children with HIV . TCD suggests atypical intracranial vessels and/or haemodynamics in some children with HIV infection, consistent with vasculopathy, possibly related directly to immunodeficiency and/or infection. What this paper adds A range of stroke syndromes are found in children with human immunodeficiency virus (HIV). Transcranial Doppler (TCD) velocities in HIV are commonly outside the range for typically developing children. TCD and neuroimaging data in children with HIV suggest intracranial vasculopathy as one mechanism for stroke. CD4 cell count is non‐significantly lower in children with HIV and atypical TCD.