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Fatigue in young people with Duchenne muscular dystrophy
Author(s) -
ElAloul Basmah,
Speechley Kathy N,
Wei Yi,
Wilk Piotr,
Campbell Craig
Publication year - 2020
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.14248
Subject(s) - duchenne muscular dystrophy , medicine , physical therapy , quality of life (healthcare) , disease , neuromuscular disease , pediatrics , sleep disorder , muscular dystrophy , psychiatry , cognition , nursing
Aim To describe fatigue in Duchenne muscular dystrophy ( DMD ) from patients’ and parents’ perspectives and to explore risk factors for fatigue in children and adolescents with DMD . Method A multicentre, cross‐sectional study design was used. Seventy‐one patients (all males; median age 12y, age range 5–17y) identified via the Canadian Neuromuscular Disease Registry, and their parents completed questionnaires. Subjective fatigue was assessed using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale by child self‐report and parent proxy‐report. Results Patients with DMD across ages and disease stages experienced greater fatigue compared to typically developing controls from published data. Sleep disturbance symptoms were associated with greater fatigue by child self‐report ( ρ =–0.42; p =0.003) and parent proxy‐report ( ρ =–0.51; p <0.001). Depressive symptoms were associated with greater fatigue by child self‐report ( ρ =–0.46; p <0.001) and parent proxy‐report ( ρ =–0.45; p <0.001). Lower functional ability was associated with greater fatigue by parent proxy‐report ( ρ =0.26; p =0.03). Physical activity level, and musculoskeletal, respiratory, and cardiac function were not associated with fatigue. Interpretation In paediatric DMD , sleep disturbance symptoms and depressive symptoms are potentially modifiable factors associated with fatigue, warranting additional investigation to facilitate the development of therapeutic strategies to reduce fatigue. What this paper adds Fatigue is a major issue in paediatric Duchenne muscular dystrophy (DMD) across ages and disease stages. Sleep disturbance and depressive symptoms are significantly associated with fatigue in paediatric DMD.