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Motor function in children with congenital Zika syndrome
Author(s) -
Melo Adriana,
Gama Gabriela L,
Da Silva Júnior Renan A,
De Assunção Paula L,
Tavares Jousilene S,
Da Silva Mariana B,
Costa Kamila N F S,
Vânia Mell L,
Evangelista Morgana A,
De Amorim Melania M R
Publication year - 2020
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.14227
Subject(s) - interquartile range , motor function , pediatrics , medicine , medical record , gross motor skill , motor skill , gross motor function classification system , microcephaly , physical medicine and rehabilitation , cerebral palsy , psychiatry
Aim To evaluate gross motor function and associated factors in children with congenital Zika syndrome ( CZS ). Method Fifty‐nine children (30 males, 29 females) with CZS at a mean ( SD ) age of 14.7 (3.9), months (range 5–29mo) were evaluated using the Gross Motor Function Measure ( GMFM ) and classified according to the Gross Motor Function Classification System ( GMFCS ). Neurological damage was evaluated by neuroimaging. The mothers’ sociodemographic characteristics and general data on the children were obtained from interviews with the mothers and from the children's medical records. Correlational and multiple regression analyses were performed to identify factors associated with these children's motor function. Results In 81% of the children, motor function impairment was severe, classified as GMFCS level V. The overall GMFM score ranged from 5 to 210 (median 18; interquartile range 11), with only four children receiving scores in the D and E dimensions. The factors found to affect motor function were the presence of severe malformations of cortical development and small head circumference at birth. Interpretation Although motor impairment may be mild in some children, it is generally severe. Severe malformations of cortical development and small head circumference at birth were factors associated with poorer motor function, reflecting the greater severity of brain damage. What this paper adds Motor impairment is severe in most children with congenital Zika syndrome (CZS). Motor skills are adequate or close to adequate for age in 7% of children with CZS. Severe malformations of cortical development are associated with poor motor control. Small head circumference at birth is also associated with poor motor control.