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Apolipoprotein E gene polymorphisms and intraventricular haemorrhage in infants born preterm: a large prospective multicentre cohort study
Author(s) -
Dzietko Mark,
Schulz Soeren,
Preuss Michael,
Haertel Christoph,
Stein Anja,
FelderhoffMueser Ursula,
Goepel Wolfgang
Publication year - 2019
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.13987
Subject(s) - apolipoprotein e , medicine , odds ratio , intraventricular hemorrhage , gestational age , genotype , prospective cohort study , hazard ratio , pediatrics , confidence interval , pregnancy , genetics , biology , disease , gene
Aim Infants born preterm are at risk of intraventricular haemorrhage ( IVH ) but individual susceptibility related to genes is not well defined in this vulnerable population. Apolipoprotein genotypes APOE 2 and APOE 4 increase the hazard of cerebral haemorrhages in adults. We investigated whether APOE is associated with prevalence of IVH and is likely to have a particular genotype. Method In this prospective study, 5075 infants born preterm with genotype APOE 3 were compared to 965 ( APOE 2 ) and 1912 ( APOE 4 ) individuals, to analyse the association between APOE genotype and grade III and IV IVH . We used a logistic regression model including gestational age, antenatal steroid treatment, 5‐minute Apgar scores less than 3, intubation, pneumothorax, small for gestational age, multiple birth, sex, and maternal descent as independent factors. Results The APOE 2 (20.1%) and APOE 4 (19.8%) genotypes were significantly more prevalent in infants with IVH than in those with the APOE 3 haplotype (17.4%) ( APOE 2 : odds ratio [ OR ] 1.33, 95% confidence interval [ CI ] 1.00–1.76; APOE 4 : OR 1.39, 95% CI 1.12–1.74). Infants with two polymorphisms had the highest risk of IVH (8.7%; OR 1.63, 95% CI 1.09–2.45). Interpretation APOE 2 and APOE 4 genotypes are relevant risk factors for IVH in infants born preterm. Our findings improve our understanding of the genetic contributions to IVH .