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Health‐related quality of life of children and adolescents with cerebral palsy in low‐ and middle‐income countries: a systematic review
Author(s) -
Power Rosalie,
King Catherine,
Muhit Mohammad,
Heanoy Eamin,
Galea Claire,
Jones Cheryl,
Badawi Nadia,
Khandaker Gulam
Publication year - 2018
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.13681
Subject(s) - cerebral palsy , respondent , low and middle income countries , quality of life (healthcare) , medicine , gross motor function classification system , pediatrics , child health , cohort , developing country , physical therapy , nursing , political science , pathology , economic growth , law , economics
Aim To systematically review literature on health‐related quality of life ( HRQ oL) of children and adolescents (≤18yo) with cerebral palsy ( CP ) from low‐ and middle‐income countries ( LMIC s) to identify trends in HRQ oL and areas for future research. Method We systematically reviewed six key bibliographic databases and two reviewers independently screened results. Peer‐reviewed original articles examining HRQ oL of children from LMIC s were eligible. Results A total of 22 524 papers were identified, of which 16, from eight LMIC s, were included. Four measures of HRQ oL were used; Child Health Questionnaire Parent Form 50 ( n =5); Paediatric Quality of Life Inventory 3.0 and 4.0 ( n =4); CP Quality of Life Questionnaire for Children ( n =4); Lifestyle Assessment Questionnaire CP ( n =3). Children with CP from LMIC s ( n =1579; 2–18y) had significantly poorer HRQ oL on all instrument dimensions when compared to age‐matched controls ( p <0.003) and on all except two dimensions when compared to peers in high‐income countries ( p <0.001). Physical well‐being dimensions of HRQ oL were poorest overall and associated with impaired motor function. Interpretation Research to improve HRQ oL in LMIC s is required and should address all aspects of HRQ oL. Future research is recommended to incorporate multi‐respondent assessment, utilize both general and CP ‐specific measures of HRQ oL, and delineate adolescents as a unique cohort.What this paper adds Children with cerebral palsy from low‐ and middle‐income countries are at high risk of poor health‐related quality of life (HRQoL). Physical well‐being was poorest dimension of HRQoL and associated with impaired motor function.