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Preterm and term‐equivalent age general movements and 1‐year neurodevelopmental outcomes for infants born before 30 weeks' gestation
Author(s) -
Olsen Joy E,
Allinson Leesa G,
Doyle Lex W,
Brown Nisha C,
Lee Katherine J,
Eeles Abbey L,
Cheong Jeanie L Y,
Spittle Alicia J
Publication year - 2018
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.13558
Subject(s) - medicine , odds ratio , gestation , pediatrics , gestational age , movement assessment , confidence interval , full term , motor skill , pregnancy , genetics , psychiatry , biology
Aim To examine the associations between Prechtl's General Movements Assessment ( GMA ), conducted from birth to term‐equivalent age, and neurodevelopmental outcomes at 12 months corrected age, in infants born very preterm. Method One hundred and thirty‐seven infants born before 30 weeks' gestation had serial GMA (categorized as ‘normal’ or ‘abnormal’) before term and at term‐equivalent age. At 12 months corrected age, neurodevelopment was assessed using the Alberta Infant Motor Scale ( AIMS ); Neurological, Sensory, Motor, Developmental Assessment ( NSMDA ); and Touwen Infant Neurological Examination ( TINE ). The relationships between GMA at four time points and 12‐month neurodevelopmental assessments were examined using regression models. Results Abnormal GMA at all time points were associated with worse continuous scores on the AIMS , NSMDA , and TINE ( p <0.05). Abnormal GMA before term and at term‐equivalent age were associated with increased odds of mild–severe dysfunction on the NSMDA (odds ratio [ OR ] 4.26, 95% confidence interval [ CI ] 1.55–11.71, p <0.01; and OR 4.16, 95% CI 1.55–11.17, p <0.01 respectively) and abnormal GMA before term with increased odds of suboptimal–abnormal motor function on the TINE ( OR 2.75, 95% CI 1.10–6.85, p =0.03). Interpretation Abnormal GMA before term and at term‐equivalent age were associated with worse neurodevelopment at 12 months corrected age in children born very preterm. What this paper adds Abnormal general movements before term predict developmental deficits at 1 year in infants born very preterm. General Movements Assessment before term identifies at‐risk infants born very preterm.