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Risk of stroke among patients with cerebral palsy: a population‐based cohort study
Author(s) -
Wu ChinWen,
Huang ShihWei,
Lin JiaWei,
Liou TsanHon,
Chou LinChuan,
Lin HuiWen
Publication year - 2017
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.13180
Subject(s) - hazard ratio , medicine , stroke (engine) , cerebral palsy , confounding , confidence interval , proportional hazards model , cohort study , population , risk factor , prospective cohort study , cohort , pediatrics , physical therapy , environmental health , mechanical engineering , engineering
Aim The aim of the study was to investigate the risk of stroke in patients with cerebral palsy ( CP ), based on nationwide data in Taiwan. Method This prospective cohort study was comprised of patients recorded on the Taiwan Longitudinal Health Insurance Database 2005 ( LHID 2005) who had a diagnosis of CP ( n =1975) in records between 1 January 2004 and 31 December 2007. A comparison group (1:5) drawn from the same database was matched for age and sex ( n =9875). Each patient was tracked by data until the development of stroke or the end of 2008. Cox proportional‐hazards regression analysis was used to evaluate the hazard ratios after adjusting for potential confounding factors. Results Patients with CP were more likely to suffer stroke than the comparison population, after adjusting for potential confounding factors (adjusted hazard ratio: 2.17; 95% confidence interval [ CI ]: 1.74–2.69). The hazard ratio of stroke was 4.78 (95% CI : 3.18–7.17) and 1.57 (95% CI : 1.20–2.05) for patients with CP aged 50 years and under, and over 50 years respectively. Interpretation Cerebral palsy is a risk factor or marker for stroke that is independent of traditional stroke risk factors. Further research in this area is warranted.