Premium
Mesenchymal stem cell application in children with subacute sclerosing panencephalitis
Author(s) -
Kuşkonmaz Bariş,
Uçkan Duygu,
Yalnizoğlu Dilek,
Günel Mintaze,
Karli Oğuz Kader,
Konuşkan Bahadir,
Anlar Banu
Publication year - 2015
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.12747
Subject(s) - subacute sclerosing panencephalitis , medicine , mesenchymal stem cell , magnetic resonance imaging , disease , electroencephalography , stage (stratigraphy) , pathology , pediatrics , radiology , measles , measles virus , psychiatry , vaccination , paleontology , biology
Subacute sclerosing panencephalitis ( SSPE ) is a serious, often fatal disease that responds poorly to current treatment modalities. Recently, the ability of mesenchymal stem cells ( MSC s) to produce neurotrophic factors and inflammatory molecules has placed them among potential treatment agents for neurological conditions. We report the results of four patients treated with MSC for SSPE . The patients were followed up clinically, and by periodical laboratory evaluations, magnetic resonance imaging ( MRI ), and electroencephalography. One patient deteriorated to stage III of the disease, two patients remained in the same stage, and one died from disease progression and respiratory problems. Neurological findings and electroencephalography scores were consistent with the clinical course of the patient whereas MRI showed new inflammatory lesions in two patients. This is the first report of the application of MSC in SSPE . No benefit is demonstrated.