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Can preoperative cranial ultrasound predict early neurodevelopmental outcome in infants with congenital heart disease?
Author(s) -
Latal Beatrice,
Kellenberger Christian,
Dimitropoulos Anastasia,
Hagmann Cornelia,
Balmer Christian,
Beck Ingrid,
Bernet Vera
Publication year - 2015
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.12701
Subject(s) - medicine , bayley scales of infant development , psychomotor learning , pediatrics , intraventricular hemorrhage , heart disease , cohort , prospective cohort study , white matter , cardiology , surgery , magnetic resonance imaging , gestational age , radiology , cognition , pregnancy , genetics , psychiatry , biology
Aim To determine the role of preoperative cranial ultrasound ( cUS ) in predicting neurodevelopmental outcome in infants undergoing bypass surgery for congenital heart disease ( CHD ). Method Prospective cohort study on 77 infants (44 males, 33 females) operated before 3 months of age (median age at surgery 10d [range 3–88d]) who received at least one preoperative cUS . Outcome at 1 year was assessed with a standardized neurological examination and the Bayley Scales of Infant Development II (mental developmental index [ MDI ]; psychomotor developmental index [ PDI ]). Results Abnormalities on cUS were detected in 22 (29%) infants and consisted of diffuse brain oedema ( n =12, 16%), periventricular white matter injury ( n =5, 6%), ventricular dilatation ( n =3, 4%), and intraventricular haemorrhage ( IVH ) ( n =2, 3%). Infants undergoing balloon‐atrial septostomy ( BAS ) had a higher rate of subsequent brain oedema than those without BAS ( p =0.006). cUS abnormalities were not related to neurodevelopmental outcome. Interpretation Preoperative cUS findings in infants undergoing bypass surgery for CHD occur rather frequently, consisting of mild lesions such as brain oedema or white matter changes. These findings, however, do not correlate with early neurodevelopmental outcome.