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Distinct patterns of cortical thinning in concurrent motor and attention disorders
Author(s) -
Langevin Lisa Marie,
MacMaster Frank P,
Dewey Deborah
Publication year - 2015
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.12561
Subject(s) - neuropsychology , neurodevelopmental disorder , psychology , attention deficit hyperactivity disorder , neuroimaging , neuroscience , audiology , medicine , cognition , psychiatry , autism
Aim Many neurodevelopmental disorders co‐occur yet are rarely studied in terms of brain development. Developmental coordination disorder ( DCD ) and attention‐deficit–hyperactivity disorder ( ADHD ) co‐occur at a high frequency and are associated with functional and structural brain alterations. The objective of this study was to examine whether the effects of comorbid motor and attention problems influence cortical thickness in children and whether the pattern of changes for concurrent disorders is distinct from the alterations seen in single disorders. Method A total of 34 children (19 males, 15 females, mean age 9y 9mo, range 8–17y) who met the criteria for DCD ( n =14), ADHD ( n =10), or DCD + ADHD ( n =10) were recruited into the study. Fourteen participants with typical development (eight males, six females, mean age 11y 9mo, range 8–17y) were also recruited for comparison. Participants underwent neuropsychological assessment and magnetic resonance imaging. Cortical thickness analysis was performed to determine the patterns of cortical thinning in each disorder, which was then compared across groups. Results Children with comorbid DCD + ADHD demonstrated more widespread decreases in cortical thickness than participants with a diagnosis of DCD or ADHD alone. Cortical thinning was found to be concentrated in the frontal, parietal, and temporal lobes, and was correlated with measures of motor and attentional functioning. Interpretation The co‐occurrence of DCD + ADHD was associated with a distinct global pattern of regional cortical thickness decrease, highlighting the unique neurobiology of comorbid neurodevelopmental disorders. This novel feature of concurrent DCD and ADHD may help inform diagnostic definitions and provide clues to both the shared and the isolated genetic and environmental origins of motor and attention disorders.