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An investigation into the relationship between vigabatrin, movement disorders, and brain magnetic resonance imaging abnormalities in children with infantile spasms
Author(s) -
Fong Choong YI,
Osborne John P,
Edwards Stuart W,
Hemingway Cheryl,
Hancock Eleanor,
Johnson Anthony L,
Kennedy Colin R,
Kneen Rachel,
Likeman Marcus,
Lux Andrew L,
Mordekar Santosh R,
Murugan Velayutham,
Newton Richard W,
Pike Michael,
Quinn Michael,
Spinty Stefan,
Vassallo Grace,
Verity Christopher M,
Whitney Andrea,
O'Callaghan Finbar J K
Publication year - 2013
Publication title -
developmental medicine and child neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.658
H-Index - 143
eISSN - 1469-8749
pISSN - 0012-1622
DOI - 10.1111/dmcn.12188
Subject(s) - vigabatrin , magnetic resonance imaging , pediatrics , medicine , movement disorders , psychology , anticonvulsant , epilepsy , psychiatry , radiology , disease
Aim We aimed to investigate the relationship between movement disorders, changes on brain magnetic resonance imaging ( MRI ), and vigabatrin therapy in children with infantile spasms. Method Retrospective review and brain MRI analysis of children enrolled in the I nternational C ollaborative I nfantile S pasms S tudy ( ICISS ) who developed a movement disorder on vigabatrin therapy. Comparisons were made with controls within ICISS who had no movement disorder. Results Ten of 124 infants had a movement disorder and in eight it had developed on vigabatrin therapy. Two had a movement disorder that resolved on dose‐reduction of vigabatrin, one had improvement on withdrawing vigabatrin, two had resolution without any dose change, and in three it persisted despite vigabatrin withdrawal. The typical brain MRI changes associated with vigabatrin therapy were noted in two infants. Ten control infants were identified. Typical MRI changes noted with vigabatrin were noted in three controls. Interpretation It is possible that in two out of eight cases, vigabatrin was associated with the development of a movement disorder. In six out of eight cases a causal relationship was less plausible. The majority of infants treated with vigabatrin did not develop a movement disorder. MRI changes associated with vigabatrin do not appear to be specifically related to the movement disorder.