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Pluripotent stem cells for the study of early human embryology
Author(s) -
Semi Katsunori,
Takashima Yasuhiro
Publication year - 2021
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12715
Subject(s) - epiblast , induced pluripotent stem cell , embryonic stem cell , stem cell , microbiology and biotechnology , embryoid body , biology , germ layer , genetics , gastrulation , gene
Forty years have passed since the first pluripotent stem cells (PSCs), mouse embryonic stem cells (ESCs), were established. Since then, several PSCs have been reported, including human ESCs in 1998, mouse epiblast stem cells (EpiSCs) in 2007, induced PSCs (iPSCs) in 2006 and 2007, and naïve human PSCs in 2014. Naïve PSCs are thought to correspond to pre‐implantation epiblast cells, whereas conventional (or primed) human PSCs correspond to post‐implantation epiblast cells. Thus, naïve and primed PSCs are classified by their developmental stages and have stage‐specific characteristics, despite sharing the common feature of pluripotency. In this review, we discuss the current status of PSCs and their use to model human peri‐implantation development.