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Decoding the Notch signal
Author(s) -
FaloSanjuan Julia,
Bray Sarah J.
Publication year - 2020
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12644
Subject(s) - notch signaling pathway , transcription factor , context (archaeology) , signalling , transcription (linguistics) , biology , decoding methods , transcriptional activity , key (lock) , computational biology , signal transduction , gene , microbiology and biotechnology , neuroscience , genetics , computer science , telecommunications , paleontology , linguistics , philosophy , ecology
Notch signalling controls many key cellular processes which differ according to the context where the pathway is deployed due to the transcriptional activation of specific sets of genes. The pathway is unusual in its lack of amplification, also raising the question of how it can efficiently activate transcription with limited amounts of nuclear activity. Here, we focus on mechanisms that enable Notch to produce appropriate transcriptional responses and speculate on models that could explain the current gaps in knowledge.