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Effects of Notch glycosylation on health and diseases
Author(s) -
Urata Yusuke,
Takeuchi Hideyuki
Publication year - 2020
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12643
Subject(s) - notch signaling pathway , biology , notch proteins , glycosylation , cyclin dependent kinase 8 , hes3 signaling axis , microbiology and biotechnology , signal transduction , extracellular , glycan , cell signaling , crosstalk , genetics , glycoprotein , physics , optics
Notch signaling is an evolutionarily conserved signaling pathway and is essential for cell‐fate specification in metazoans. Dysregulation of Notch signaling results in various human diseases, including cardiovascular defects and cancer. In 2000, Fringe, a known regulator of Notch signaling, was discovered as a Notch‐modifying glycosyltransferase. Since then, glycosylation—a post‐translational modification involving literal sugars—on the Notch extracellular domain has been noted as a critical mechanism for the regulation of Notch signaling. Additionally, the presence of diverse O ‐glycans decorating Notch receptors has been revealed in the extracellular domain epidermal growth factor‐like (EGF) repeats. Here, we concisely summarize the recent studies in the human diseases associated with aberrant Notch glycosylation.