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Mechanistic insights from the LHX1‐driven molecular network in building the embryonic head
Author(s) -
McMahon Riley,
Sibbritt Tennille,
Salehin Nazmus,
Osteil Pierre,
Tam Patrick P. L.
Publication year - 2019
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12609
Subject(s) - transcription factor , homeobox , biology , wnt signaling pathway , microbiology and biotechnology , embryonic stem cell , xenopus , gene , genetics , signal transduction
Development of an embryo is driven by a series of molecular instructions that control the differentiation of tissue precursor cells and shape the tissues into major body parts. LIM homeobox 1 (LHX1) is a transcription factor that plays a major role in the development of the embryonic head of the mouse. Loss of LHX1 function disrupts the morphogenetic movement of head tissue precursors and impacts on the function of molecular factors in modulating the activity of the WNT signaling pathway. LHX1 acts with a transcription factor complex to regulate the transcription of target genes in multiple phases of development and in a range of embryonic tissues of the mouse and Xenopus . Determining the interacting factors and transcriptional targets of LHX1 will be key to unraveling the ensemble of factors involved in head development and building a head gene regulatory network.