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Zebrafish as a model for studying functional pancreatic β cells development and regeneration
Author(s) -
Matsuda Hiroki
Publication year - 2018
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12565
Subject(s) - zebrafish , pancreas , regeneration (biology) , islet , biology , microbiology and biotechnology , glucose homeostasis , homeostasis , pancreatic islets , regenerative medicine , diabetes mellitus , stem cell , endocrinology , insulin resistance , genetics , gene
Pancreatic β cells produce insulin and play a central role in glucose homeostasis. The regenerative capacity of mammalian β cells is limited, so that loss and dysfunction of β cells causes diabetes. Zebrafish have a pancreas which is functionally and morphologically conserved with human pancreas. Zebrafish have high regenerative capacity of islets. In the present review, development of zebrafish pancreas was described in comparison to that of mammals, and the regenerative process of zebrafish pancreas was also described. This review will give information on understanding islet and pancreatic β cell development and regeneration and provide possibilities of zebrafish research for developing new diabetic therapies and regenerative medicines.