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Roles of Xenopus chemokine ligand CXCL h ( XCXCL h ) in early embryogenesis
Author(s) -
Goto Toshiyasu,
Ito Yuzuru,
Michiue Tatsuo
Publication year - 2018
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12432
Subject(s) - xenopus , embryogenesis , microbiology and biotechnology , biology , chemokine , chemistry , receptor , embryo , genetics , gene
Several chemokine molecules control cell movements during early morphogenesis. However, it is unclear whether chemokine molecules affect cell fate. Here, we identified and characterized the CXC ‐type chemokine ligand in Xenopus laevis , Xenopus CXCL h ( XCXCL h) , during early embryogenesis. XCXCL h is expressed in the dorsal vegetal region at the gastrula stage. Both overexpression and knockdown of XCXCL h in the dorsal region inhibited gastrulation. XCXCL h contributed to the attraction of mesendodermal cells and accelerated the reassembly of scratched culture cells. Also, XCXCL h contributed to early endodermal induction. Overexpression of VegT mRNA or high concentrations of calcium ions induced XCXCL h expression. XCXCL h may play roles in both cell movements and differentiation during early Xenopus embryogenesis.