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Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions
Author(s) -
Blume Marissa,
Inoguchi Fuduki,
Sugiyama Taku,
Owada Yuji,
Osumi Noriko,
Aimi Yoshinari,
Taki Kosuke,
Katsuyama Yu
Publication year - 2017
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12393
Subject(s) - dab1 , reelin , subiculum , dentate gyrus , reeler , hippocampal formation , neocortex , hippocampus , biology , neurogenesis , neuroscience , morphogenesis , microbiology and biotechnology , anatomy , genetics , gene , extracellular matrix
The hippocampal formation ( HF ) is morphologically and functionally distinguishable into the subdivisions, such as the dentate gyrus ( DG ), subiculum, and Ammon's horn. The Ammon's horn is further divided into the CA (Cornu Ammonis)1, CA 2, and CA 3. The Reelin‐Dab1 signal is essential for the morphogenesis of the mammalian brain. In the neocortex of Reelin‐Dab1 signal mutants the laminar pattern of the neurons is disrupted along the radial axis. Morphological abnormalities in the HF of the Reelin‐Dab1 mutants were known, but how these abnormalities appear during development had not been extensively studied. We examined the morphology of the well‐developed Dab1 deficient HF by staining with a silver impregnation method in this report, and found that disruption of lamination in the CA 1, CA 3, and DG was different. Abnormalities observed in the development of Dab1 deficient CA 1 were similar to those reported in the neocortical development, while Dab1 deficient CA 3 neuronal progenitors radially spreaded beyond presumptive pyramidal layer. The intermediate progenitor cells ectopically located in the Dab1 deficient DG , but neurogenesis was normal in the CA 1 and CA 3. These observations suggest that the morphogenesis in these HF subdivisions employs different developmental mechanisms involving Dab1 function.