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Role of domain in pattern formation
Author(s) -
SeirinLee Sungrim
Publication year - 2017
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12377
Subject(s) - pattern formation , domain (mathematical analysis) , chromatin , mechanism (biology) , biological system , computer science , field (mathematics) , computational biology , biology , dna , mathematics , physics , genetics , mathematical analysis , quantum mechanics , pure mathematics
Pattern formation during development is one of the elegant self‐organized phenomena that allow cells to regulate their functions. At all levels, from DNA to a tissue or organ, many developmental processes include the determination of cellular functions through pattern formation. To elucidate the mechanism underlying pattern formation, numerous mathematical models have been developed and applied. However, model simplification has resulted in the role of domains not being seriously considered in pattern formation. Here, we introduce a novel application of the phase‐field method for analysis of chromatin dynamics, and a mathematical approach that includes domain information into a biochemical model of pattern formation. Using this new modeling method, here, we consider the role of nuclear and cellular cell shapes on pattern formation.