Premium
Shape and geometry control of the Drosophila tracheal tubule
Author(s) -
Hayashi Shigeo,
Dong Bo
Publication year - 2017
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12336
Subject(s) - tubule , extracellular matrix , drosophila (subgenus) , elongation , cortex (anatomy) , matrix (chemical analysis) , biophysics , anatomy , geometry , microbiology and biotechnology , biology , chemistry , materials science , neuroscience , mathematics , gene , genetics , composite material , ultimate tensile strength , kidney , chromatography
For efficient respiration, tubular airways must be constructed with an optimal diameter and length for the dimensions of the body. In Drosophila, the growth of embryonic tracheal tubules proceeds in two dimensions, by axial elongation and diameter expansion. The growth forces in each dimension are controlled by distinct genetic programs and cellular mechanisms. Recent studies reveal that the apical cortex and the apical extracellular matrix filling the luminal space are essential for the generation, balancing, and equilibrium of these growth forces. We here discuss the mechanical properties and architecture of the apical cortex and extracellular matrix, and their crucial roles in the tissue‐level coordination of tubule shape and geometry.