Premium
Fgf8 signaling for development of the midbrain and hindbrain
Author(s) -
Harada Hidekiyo,
Sato Tatsuya,
Nakamura Harukazu
Publication year - 2016
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12293
Subject(s) - hindbrain , fgf8 , midbrain , biology , neuroscience , rhombomere , microbiology and biotechnology , anatomy , central nervous system , genetics , receptor , gene expression , hox gene , gene , fibroblast growth factor
In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary ( MHB ), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hindbrain. Fgf8 induces En1 and Pax2 expression at the region where Otx2 is expressed to specify midbrain. Fgf8 activates Ras‐ ERK pathway to specify hindbrain. Downstream of ERK , Pea3 specifies isthmus (rhombomere 0, r0), and Irx2 may specify r1, where the cerebellum is formed.