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Genetic oscillators in development
Author(s) -
Uriu Koichiro
Publication year - 2016
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12262
Subject(s) - somitogenesis , biology , gene regulatory network , live cell imaging , developmental biology , gene expression , regulation of gene expression , cell fate determination , neuroscience , gene , computational biology , microbiology and biotechnology , cell , genetics , transcription factor , embryonic stem cell , somite
In development, morphogenetic processes are strictly coordinated in time. Cells in a developing tissue would need mechanisms for time‐keeping. One such time‐keeping mechanism is to use oscillations of gene expression. Oscillatory gene expression can be generated by transcriptional/translational feedback loops, usually referred to as a genetic oscillator. In this review article, we discuss genetic oscillators in the presence of developmental processes such as cell division, cell movement and cell differentiation. We first introduce the gene regulatory network for generating a rhythm of gene expression. We then discuss how developmental processes influence genetic oscillators. Examples include vertebrate somitogenesis and neural progenitor cell differentiation, as well as the circadian clock for comparison. To understand the behaviors of genetic oscillators in development, it is necessary to consider both gene expression dynamics and cellular behaviors simultaneously. Theoretical modeling combined with live imaging at single‐cell resolution will be a powerful tool to analyze genetic oscillators in development.

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