Premium
miR‐29a modulates tumor necrosis factor‐ α ‐induced osteogenic inhibition by targeting Wnt antagonists
Author(s) -
Li Caixia,
Zhang Pingping,
Gu Jieruo
Publication year - 2015
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12207
Subject(s) - wnt signaling pathway , ankylosing spondylitis , tumor necrosis factor alpha , inflammation , cancer research , pathogenesis , medicine , bone remodeling , catenin , tumor necrosis factor α , immunology , signal transduction , biology , microbiology and biotechnology
We previously found that miR‐29a was significantly downregulated in Ankylosing spondylitis ( AS ) patients, a chronic inflammatory disease associated with bone metabolic disorder, however, the underlying mechanism remains unclear. In this study, we demonstrated that miR‐29a regulates tumor necrosis factor‐ α ( TNF ‐ α ) mediated bone loss mainly by targeting DKK 1 and GSK 3 β , thus activating the Wnt/β‐catenin pathway. Our findings may provide new insight into the pathogenesis of the bone metabolism disorder in inflammation environment and provide promising therapeutic target.