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Engrailed and tectum development
Author(s) -
Omi Minoru,
Nakamura Harukazu
Publication year - 2015
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12197
Subject(s) - tectum , midbrain , engrailed , neuroscience , biology , laminar organization , tegmentum , optic tectum , superior colliculi , anatomy , retina , visual system , central nervous system , homeobox , gene expression , gene , biochemistry
The optic tectum is a visual center of nonmammalian vertebrates derived from the mesencephalon. In this review, function of Engrailed (En) in tectum development is reviewed. En plays crucial roles at three steps of tectum development. First, Engrailed is expressed in the mesencephalon and the metencephalon and essential for the regionalization of the mesencephalon. En is expressed in a gradient of caudal‐to‐rostral in the tectum primordial, and regulates the rostrocaudal polarity of the tectum. In the advanced stage of tectum development, En is expressed in a lamina‐specific manner and it is suggested that En regulates cell migration in the tectal laminar formation.