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Periostin, a neurite outgrowth‐promoting factor, is expressed at high levels in the primate cerebral cortex
Author(s) -
Matsunaga Eiji,
Nambu Sanae,
Oka Mariko,
Tanaka Michio,
Taoka Miki,
Iriki Atsushi
Publication year - 2015
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12194
Subject(s) - periostin , neurite , cerebral cortex , neuroscience , neuroplasticity , cortex (anatomy) , primate , biology , microbiology and biotechnology , extracellular matrix , neuroprotection , in vitro , biochemistry
Periostin ( POSTN or osteoblast specific factor) is an extracellular matrix protein originally identified as a protein highly expressed in osteoblasts. Recently, periostin has been reported to function in axon regeneration and neuroprotection. In the present study, we focused on periostin function in cortical evolution. We performed a comparative gene expression analysis of periostin between rodents (mice) and primates (marmosets and macaques). Periostin was expressed at higher levels in the primate cerebral cortex compared to the mouse cerebral cortex. Furthermore, we performed overexpression experiments of periostin in vivo and in vitro . Periostin exhibited neurite outgrowth activity in cortical neurons. These results suggested the possibility that prolonged and increased periostin expression in the primate cerebral cortex enhances the cortical plasticity of the mammalian cerebral cortex.