Histone deacetylase inhibitor sodium butyrate promotes the osteogenic differentiation of rat adipose‐derived stem cells | Zendy

Hu Xiaoqing | Zendy; Fu Yutuo | Zendy; Zhang Xin | Zendy; Dai Linghui | Zendy; Zhu Jingxian | Zendy; Bi Zhenggang | Zendy; Ao Yingfang | Zendy; Zhou Chunyan | Zendy

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Histone deacetylase inhibitor sodium butyrate promotes the osteogenic differentiation of rat adipose‐derived stem cells

Author(s) -

Hu Xiaoqing,

Fu Yutuo,

Zhang Xin,

Dai Linghui,

Zhu Jingxian,

Bi Zhenggang,

Ao Yingfang,

Zhou Chunyan

Publication year - 2014

Publication title -

development, growth and differentiation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.864

H-Index - 66

eISSN - 1440-169X

pISSN - 0012-1592

DOI - 10.1111/dgd.12119

Subject(s) - sodium butyrate , biology , adipose tissue , histone deacetylase inhibitor , histone deacetylase , microbiology and biotechnology , butyrate , stem cell , histone , pharmacology , cancer research , endocrinology , biochemistry , gene , fermentation

Adult stem cells hold great promise for use in tissue repair and regeneration. Recently, adipose tissue‐derived stem cells ( ADSC s) were found to be an appealing alternative to bone marrow stem cells ( BMSC s) for bone tissue engineering. The main benefit of ADSC s is that they can be easily and abundantly available from adipose tissue. However, our prior study discovered an important phenomenon that BMSC s have greater osteogenic potential than ADSC s in vitro and epigenetic regulation plays a critical role in runt‐related transcription factor 2 (Runx2) expression and thus osteogenesis. In this study, we aimed to improve the osteogenic potential of ADSC s by histone deacetylase inhibitor sodium butyrate (NaBu). We found that NaBu promoted rat ADSC osteogenic differentiation by altering the epigenetic modifications on the Runx2 promoter.

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