Premium
Common marmoset as a new model animal for neuroscience research and genome editing technology
Author(s) -
Kishi Noriyuki,
Sato Kenya,
Sasaki Erika,
Okano Hideyuki
Publication year - 2014
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12109
Subject(s) - marmoset , callithrix , neuroscience , biology , cognitive science , computer science , computational biology , evolutionary biology , psychology , ecology
The common marmoset ( C allithrix jacchus ) is a small N ew W orld primate; it originally comes from the A tlantic coastal forests in northeastern B razil. It has been attracting much attention in the biomedical research field because of its size, availability, and unique biological characteristics. Its endocrinological and behavioral similarity to humans, comparative ease in handling, and high reproductive efficiency are very advantageous for neuroscience research. Recently, we developed transgenic common marmosets with germline transmission, and this technological breakthrough provides a potential paradigm shift by enabling researchers to investigate complex biological phenomena using genetically‐modified non‐human primates. In this review, we summarize recent progress in marmoset research, and also discuss a potential application of genome editing tools that should be useful toward the generation of knock‐out/knock‐in marmoset models.