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Differentiation of PZ5 neural stem/progenitor cells. PZ5 neural stem/progenitor cells that have multipotent ability to differentiate into neurons, astrocytes or oligodendrocytes were genetically engineered to express one of channelrhodopsin variants tagged with EGFP and allowed for differentiation for 12 days. Each color represents; βIII‐tubulin (red, a marker of mature neurons), channelrhodopsin‐EGFP (green, a marker of membrane) and DAPI (blue, a maker of nuclei). Some of them are fl at with an appearance of astrocyte where as others have neuron‐line morphologies.
Publication year - 2014
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12086
Subject(s) - channelrhodopsin , neurosphere , neural stem cell , progenitor cell , biology , astrocyte , stem cell , neuroscience , microbiology and biotechnology , optogenetics , cellular differentiation , adult stem cell , genetics , gene , central nervous system