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Caspase‐7 participates in differentiation of cells forming dental hard tissues
Author(s) -
Matalova Eva,
Lesot Herve,
Svandova Eva,
Vanden Berghe Tom,
Sharpe Paul T.,
Healy Christopher,
Vandenabeele Peter,
Tucker Abigail S.
Publication year - 2013
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12066
Subject(s) - ameloblast , odontoblast , apoptosis , microbiology and biotechnology , caspase 3 , incisor , caspase , chemistry , anatomy , biology , pathology , programmed cell death , enamel paint , medicine , dentin , biochemistry , dentistry , ecology
Apoptosis during tooth development appears dependent on the apoptotic executioner caspase‐3, but not caspase‐7. Instead, activated caspase‐7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase‐7‐deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase‐7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices.