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Expression patterns of the ADAM s in early developing chicken cochlea
Author(s) -
Lin Juntang,
Yan Xin,
Wang Congrui,
Talabattula Venkata Ajay Narendra,
Guo Zhikun,
Rolfs Arndt,
Luo Jiankai
Publication year - 2013
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12051
Subject(s) - cochlea , spiral ganglion , cochlear duct , microbiology and biotechnology , disintegrin , biology , basilar membrane , anatomy , metalloproteinase , matrix metalloproteinase , genetics
Members of the ADAM (a disintegrin and metalloprotease) family are type I transmembrane proteins involved in biological processes of proteolysis, cell adhesion, cell–matrix interaction, as well as in the intracellular signaling transduction. In the present study, expression patterns of seven members of the ADAM family were investigated at the early stages of the developing cochlea by in situ hybridization. The results show that each individual ADAM is expressed and regulated in the early developing cochlea. ADAM 9, ADAM 10, ADAM 17, and ADAM 23 are initially and widely expressed in the otic vesicle at embryonic day 2.5 ( E 2.5) and in the differential elements of the cochlear duct at E 9, while ADAM 12 is expressed in acoustic ganglion cells at E 7. ADAM 22 is detectable in cochlear ganglion cells as early as from E 4 and in the basilar papilla from E 7. Therefore, the present study extends our previous results and suggests that ADAM s also play a role in the early cochlear development.