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Apicobasal polarity and neural tube closure
Author(s) -
Eom Dae Seok,
Amarnath Smita,
Agarwala Seema
Publication year - 2013
Publication title -
development, growth and differentiation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.864
H-Index - 66
eISSN - 1440-169X
pISSN - 0012-1592
DOI - 10.1111/dgd.12030
Subject(s) - neural tube , polarity (international relations) , neural plate , morphogenesis , neural fold , cell polarity , process (computing) , neurulation , convergent extension , microbiology and biotechnology , biology , neuroscience , chemistry , biophysics , materials science , cell , computer science , embryo , embryogenesis , biochemistry , gastrulation , gene , operating system
During development, a flat neural plate rolls up and closes to form a neural tube. This process, called neural tube closure, is complex and requires morphogenetic events to occur along multiple axes of the neural plate. Recent studies suggest that cell and tissue polarity play a major role in neural tube morphogenesis. While the planar cell polarity pathway is known to be involved in this process, a role for the apicobasal polarity pathway has only recently begun to be elucidated. These studies show that bone morphogenetic proteins can regulate the apicobasal polarity pathway in the neural plate in a cell cycle dependent manner. This dynamically modulates apical junctions in the neural plate, resulting in cell and tissue shape changes that help bend, shape and close the neural tube.