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The Effects of Certain Vitamins and Natural Anti‐oxidants on Ornithine Decarboxylase Activity and on Atrophic and Premalignant Changes in the Human Gastric Mucosa
Author(s) -
BUKIN Yuriy V.,
PODDUBNIY Boris K.,
KUVSHINOV Yuruy P.,
DRAUDIN-KRYLENKO Vladimir A.,
SHABANOV Michael A.
Publication year - 1996
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/den.1996.8.3.184
Subject(s) - medicine , ornithine decarboxylase , atrophic gastritis , gastroenterology , vitamin , retinol , gastric mucosa , stomach , ornithine , intestinal metaplasia , vitamin b12 , placebo , endocrinology , gastritis , pathology , biochemistry , arginine , biology , enzyme , alternative medicine , amino acid
The effects of beta‐carotene, vitamin E and a pharmaceutical complex of natural anti‐oxidants (OXY‐GARD) on abnormally high ornithine decarboxylase (ODC) activity in antral gastric mucosa of patients with atrophic gastritis (AG), accompanied by intestinal metaplasia (IM), were studied in a randomized placebo‐controlled clinical trial. In cases with H. pylori infection, preliminary eradication of this bacterium was carried out utilizing a standard chemotherapeutic schedule (de nol+metronidazole+oxytetracycline). Efficient eradication of H. pylori resulted in an ODC activity decrease of 16%, on average. It was shown that supplementation with beta‐carotene, at a daily dose of 20 mg, or with vitamin E, at a daily dose of 400 IU, produced decreases in ODC activity of 46% and 44%, respectively, by three months. Daily supplementation with 1 or 2 capsules of OXY‐GARD for three months resulted in ODC activity decreases of 23% and 48%, respectively. Taking into account that abnormally high ODC activity is associated with a high oncogenic potential and plays a specific role in tumor promotion, it is reasonable to suggest that beta‐carotene, vitamin E and OXY‐GARD act in atrophic or premalignant gastric mucosa as anti‐promoters. Preliminary data indicate that prolonged administration of these nutritional supplements, e.g. beta‐carotene for one year, to IM patients produces the maximum decrease in ODC activity at three months. We found that this decrease was accompanied by a delayed partial regression of IM in nine of 18 patients (response rate 50%, 95% confidence interval 26–74%). A study on the effects of long‐term vitamin E or OXY‐GARD supplementation on IM regression is currently in progress. (Dig Endosc 1996 ; 8 : 184–191)